Invitrogen™ KANK1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA565999

Catalog No. PIPA565999

Description

Immunogen sequence: APLGMMTGLDH YIERIQKLLA EQQTLLAENY SELAEAFGEP HSQMGSLNSQ LISTLSSINS VMKSASTEEL RNPDFQKTSL GKITGNYLGY TCKCGGLQSG SPLSSQTSQP EQEVGTSEGK PISSLDAFPT QEGTLSPVNL TDDQ Highest antigen sequence identity to the following orthologs - mouse 77%, rat 79%.

Ankyrins are membrane adaptor molecules that play important roles in the control of cytoskeleton formation by regulating actin polymerization. KANK1 (KN motif and ankyrin repeat domain-containing protein 1), also known as ANKRD15, is a 1,352 amino acid protein that contains at least 12 exons and 5 ANK repeats. It binds to beta-catenin and regulates its subcellular distribution. KANK1 is ubiquitously expressed and localizes to cytoplasm. It may function as a tumor suppressor for renal cell carcinoma. Mutations in this gene cause cerebral palsy spastic quadriplegic type 2, a central nervous system development disorder.

Specifications

• Antigen: KANK1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Kank1
• Gene Alias: A930031B09Rik; ANKRD15; ankyrin repeat domain 15; ankyrin repeat domain-containing protein 15; AU015049; AW121052; CPSQ2; D330024H06Rik; KANK; Kank1; KIAA0172; Kidney ankyrin repeat-containing protein; KN motif and ankyrin repeat domain-containing protein 1; KN motif and ankyrin repeat domains 1; mKIAA0172
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23189
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 0.3 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q14678
• Gene Symbols: Kank1
• Immunogen: Recombinant Human KANK1. Recombinant protein control fragment (Product #RP-106684).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG