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KAP-1 Polyclonal Antibody, Bethyl Laboratories
Rabbit Polyclonal Antibody
$151.31 - $568.26
Specifications
| Antigen | KAP-1 |
|---|---|
| Applications | Immunocytochemistry, Immunofluorescence, Immunohistochemistry |
| Classification | Polyclonal |
| Conjugate | Unconjugated |
| Form | Liquid |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
50-157-1434
|
Bethyl Laboratories, Inc
IHC00072T |
10 μL |
Each for $151.31
|
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50-157-1433
|
Bethyl Laboratories, Inc
IHC00072 |
100 μL |
Each for $568.26
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Description
The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Mouse, Bovine, Dog, Horse, Rabbit, Panda, Orangutan, Monkey, Gorilla, Chimpanzee, Chinese hamster
The KRAB (Kruppel-associated box) domain is about 45 amino acids in length and is a transcriptional repression domain found in numerous transcription factors. There have been identified over 220 KRAB-zinc finger protein (KRAB-ZFP) genes in the human genome. These proteins functionally repress transcription via specific interactions with KAP-1 (KRAB-associated protein 1). KAP-1 is an 835 amino acid polypeptide that contains a RING finger, B boxes, and a PHD finger. KAP-1 has been shown to form complexes with KRAB-domain transcription factors and increase the efficiency with which they mediate repression. KAP-1 has also been shown to directly interact with HP1 (heterochromatin protein 1) and KRAZ1 (Kruppel-associated box-containing zinc finger protein 1). KAP-1 directly targets KRAZ1 to the foci of centromeric heterochromatin containing HP1alpha, thus helping to regulate transcriptional repression. Studies have shown that KAP-1 mutants with the ability to bind KRAB but unable to bind HP1 leads to random distribution of KRAZ1 and strong transcriptional activation.Specifications
| KAP-1 | |
| Polyclonal | |
| Liquid | |
| RUO | |
| TBS with 0.1% BSA and 0.09% sodium azide | |
| Transcription intermediary factor 1-beta, Tripartite motif protein 28, Nuclear corepressor KAP-1, KRAB-associated protein 1, KAP-1, KRAB-interacting p | |
| TRIM28 | |
| IgG | |
| Antigen affinity chromatography | |
| Antibody |
| Immunocytochemistry, Immunofluorescence, Immunohistochemistry | |
| Unconjugated | |
| Rabbit | |
| Human | |
| Q13263 | |
| 10155 | |
| Between 1 and 50 | |
| Primary | |
| 4° C | |
| TRIM28 |
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