Invitrogen™ KappaB ras1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA520341

Catalog No. PIPA520341

Description

A suggested positive control is RAW264.7 cell lysate. PA5-20341 can be used with blocking peptide PEP-0461.

KappaB ras-1 (kappa-B-ras-1) and kappaB-ras-2 are two small proteins that similar to Ras-like small GTPases that associate with Ikappa-B (Ikappa-B), an inhibitor of the transcription factor NF-kappa-B. Ikappa-B exists in two homologous forms, Ikappa-B-alpha and Ikappa-B-beta, although Ikappa-B-beta contains a unique 47-amino acid region within its ankyrin domain. While inactive Ikappa-B-alpha-NF-kappa-B complexes can shuttle in and out of the nucleus, Ikappa-B-beta-NF-kappa-B complexes are retained exclusively in the cytoplasm. It is suggested that kappaB-ras proteins preferentially bind to the Ikappa-B-beta form through this unique insert within the ankyrin region, thus modulating the cellular location of Ikappa-B-beta and regulating the rate of degradation of Ikappa-B-beta.

Specifications

• Antigen: KappaB ras1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NKIRAS1
• Gene Alias: 2400004O09Rik; C15orf1; I1PP2A; I-kappa-B-interacting Ras-like protein 1; kappa B-ras 1; kappa B-Ras protein 1; kappaB-Ras1; KBRAS1; LANP; MAPM; MGC119787; MGC150373; NF-kappa-B inhibitor-interacting Ras-like protein 1; NFKB inhibitor interacting Ras like 1; NFKB inhibitor interacting Ras-like 1; NFKB inhibitor interacting Ras-like 1 S homeolog; NFKB inhibitor interacting Ras-like protein 1; Nkiras1; nkiras1.S; PHAP1; PHAPI; PP32; XELAEV_18033117mg
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 28512, 69721
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q8CEC5, Q9NYS0
• Gene Symbols: NKIRAS1
• Immunogen: A 15 amino acid peptide from near the carboxy terminus of human KappaB ras1.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov