Invitrogen™ KappaB ras2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA520342

Catalog No. PIPA520342

Description

A suggested positive control is RAW264.7 cell lysate. PA5-20342 can be used with blocking peptide PEP-0462.

Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.

Specifications

• Antigen: KappaB ras2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NKIRAS2
• Gene Alias: 2410003M04Rik; 4930527H08Rik; D630018G21Rik; I-kappa-B-interacting Ras-like protein 2; Kappa B-Ras protein 2; kappaB-Ras2; KBRAS2; NF-kappa-B inhibitor-interacting Ras-like protein 2; NFKB inhibitor interacting Ras like 2; NFKB inhibitor interacting Ras-like 2; NFKB inhibitor interacting Ras-like protein 2; NKIRAS2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 28511, 287707, 71966
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q9CR56, Q9NYR9
• Gene Symbols: NKIRAS2
• Immunogen: A 14 amino acid peptide from near the carboxy terminus of human KappaB ras2.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov