Invitrogen™ KappaB ras2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA530531

Catalog No. PIPA530531

Description

Recommended positive controls: A549, HeLa, HCT116. Predicted reactivity: Mouse (98%), Rat (98%), Chicken (92%), Rhesus Monkey (100%), Chimpanzee (99%), Bovine (100%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.

Specifications

• Antigen: KappaB ras2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NKIRAS2
• Gene Alias: 2410003M04Rik; 4930527H08Rik; D630018G21Rik; I-kappa-B-interacting Ras-like protein 2; Kappa B-Ras protein 2; kappaB-Ras2; KBRAS2; NF-kappa-B inhibitor-interacting Ras-like protein 2; NFKB inhibitor interacting Ras like 2; NFKB inhibitor interacting Ras-like 2; NFKB inhibitor interacting Ras-like protein 2; NKIRAS2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 28511
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.76 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q9NYR9
• Gene Symbols: NKIRAS2
• Immunogen: Recombinant protein encompassing a sequence within the center region of human NKIRAS2. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG