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Invitrogen™ KBTBD2 Polyclonal Antibody
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Catalog No. PIPA554331
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100 μL
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PIPA554331 100 μL
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Catalog No. PIPA554331 Supplier Invitrogen™ Supplier No. PA554331
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: LNVEKEETVR EAAMLWLEYN TESRSQYLSS VLSQIRIDAL SEVTQRAWFQ GLPPNDKSVV VQGLYKSMPK FFKPRLGMTK EEMMIFIEAS SENPCSLYSS VCYSPQAEKV YKLCSPPADL HKVGTVVTPD ND Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.

The KBTBD2 gene encodes the Kelch repeat and BTB (POZ) domain-containing protein 2, which is involved in various cellular processes, including protein ubiquitination and metabolic regulation. The KBTBD2 protein functions as a substrate adaptor for the Cullin-RING E3 ubiquitin ligase complex, facilitating the ubiquitination and subsequent proteasomal degradation of specific substrate proteins. This activity is crucial for maintaining cellular protein homeostasis and regulating metabolic pathways. KBTBD2 has been implicated in glucose metabolism and insulin signaling, where it plays a role in modulating the degradation of key regulatory proteins. Alterations in KBTBD2 function or expression are associated with metabolic disorders, such as obesity and type 2 diabetes. Additionally, KBTBD2's involvement in ubiquitin-mediated proteolysis underscores its significance in controlling various cellular responses and adaptations, making it a potential target for therapeutic interventions in metabolic diseases.
TRUSTED_SUSTAINABILITY

Specifications

Antigen KBTBD2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene KBTBD2
Gene Accession No. Q8IY47
Gene Alias BC022962; BKLHD1; BTB and kelch domain containing 1; BTB and kelch domain-containing protein 1; CGI-73; im:7146937; KBTBD2; kelch repeat and BTB (POZ) domain containing 2; kelch repeat and BTB domain containing 2; kelch repeat and BTB domain-containing protein 2; Kelch repeat and BTB domain-containing protein 2-like protein; KIAA1489; mKIAA1489; zgc:152954
Gene Symbols KBTBD2
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human KBTBD2. Recombinant protein control fragment (Product #RP-92867).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 25948
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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