Invitrogen™ KBTBD2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA570091

Catalog No. PIPA570091

Description

This target displays homology in the following species: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%.

The KBTBD2 gene encodes the Kelch repeat and BTB (POZ) domain-containing protein 2, which is involved in various cellular processes, including protein ubiquitination and metabolic regulation. The KBTBD2 protein functions as a substrate adaptor for the Cullin-RING E3 ubiquitin ligase complex, facilitating the ubiquitination and subsequent proteasomal degradation of specific substrate proteins. This activity is crucial for maintaining cellular protein homeostasis and regulating metabolic pathways. KBTBD2 has been implicated in glucose metabolism and insulin signaling, where it plays a role in modulating the degradation of key regulatory proteins. Alterations in KBTBD2 function or expression are associated with metabolic disorders, such as obesity and type 2 diabetes. Additionally, KBTBD2's involvement in ubiquitin-mediated proteolysis underscores its significance in controlling various cellular responses and adaptations, making it a potential target for therapeutic interventions in metabolic diseases.

Specifications

• Antigen: KBTBD2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KBTBD2
• Gene Alias: BC022962; BKLHD1; BTB and kelch domain containing 1; BTB and kelch domain-containing protein 1; CGI-73; im:7146937; KBTBD2; kelch repeat and BTB (POZ) domain containing 2; kelch repeat and BTB domain containing 2; kelch repeat and BTB domain-containing protein 2; Kelch repeat and BTB domain-containing protein 2-like protein; KIAA1489; mKIAA1489; zgc:152954
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 210973
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: 0
• Gene Symbols: KBTBD2
• Immunogen: synthetic peptide directed towards the N-terminal region of mouse KBTBD2.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG