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Invitrogen™ KBTBD2 Polyclonal Antibody
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Catalog No. PIPA570091
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100 μL
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PIPA570091 100 μL
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Catalog No. PIPA570091 Supplier Invitrogen™ Supplier No. PA570091
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Description

Rabbit Polyclonal Antibody

This target displays homology in the following species: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%.

The KBTBD2 gene encodes the Kelch repeat and BTB (POZ) domain-containing protein 2, which is involved in various cellular processes, including protein ubiquitination and metabolic regulation. The KBTBD2 protein functions as a substrate adaptor for the Cullin-RING E3 ubiquitin ligase complex, facilitating the ubiquitination and subsequent proteasomal degradation of specific substrate proteins. This activity is crucial for maintaining cellular protein homeostasis and regulating metabolic pathways. KBTBD2 has been implicated in glucose metabolism and insulin signaling, where it plays a role in modulating the degradation of key regulatory proteins. Alterations in KBTBD2 function or expression are associated with metabolic disorders, such as obesity and type 2 diabetes. Additionally, KBTBD2's involvement in ubiquitin-mediated proteolysis underscores its significance in controlling various cellular responses and adaptations, making it a potential target for therapeutic interventions in metabolic diseases.
TRUSTED_SUSTAINABILITY

Specifications

Antigen KBTBD2
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene KBTBD2
Gene Accession No. 0
Gene Alias BC022962; BKLHD1; BTB and kelch domain containing 1; BTB and kelch domain-containing protein 1; CGI-73; im:7146937; KBTBD2; kelch repeat and BTB (POZ) domain containing 2; kelch repeat and BTB domain containing 2; kelch repeat and BTB domain-containing protein 2; Kelch repeat and BTB domain-containing protein 2-like protein; KIAA1489; mKIAA1489; zgc:152954
Gene Symbols KBTBD2
Host Species Rabbit
Immunogen synthetic peptide directed towards the N-terminal region of mouse KBTBD2.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 210973
Target Species Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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