Invitrogen™ KCNAB3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA567484

Catalog No. PIPA567484

Description

Immunogen sequence: CGLITSKYDGR VPDTCRASIK GYQWLKDKVQ SEDGKKQQAK VMDLLPVAHQ Highest antigen sequence identity to the following orthologs - mouse 84%, rat 80%.

Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles and other excitable cells. The KV gene family encodes more than 30 proteins that comprise the subunits of the K+ channels, and they vary in their gating and permeation properties, subcellular distribution and expression patterns. Functional KV channels assemble as tetramers consisting of pore-forming alpha subunits (KV), which include the KV1, KV2, KV3 and KV4 proteins, and accessory or KV-subunits that modify the gating properties of the coexpressed KV subunits. KV beta.3 is an accessory K+ channel protein which regulates the activity of the pore-forming alpha subunit and alters the functional properties of Kv1.5. KV beta.3 localizes to the cytoplasm and is expressed in the brain, with highest expression detected in the cerebellum, and weakest expression seen in the frontal and temporal lobes. No KV beta.3 expression is detected in the heart, spinal cord, lung, liver, kidney, pancreas, placenta or skeletal muscle.

Specifications

• Antigen: KCNAB3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KCNAB3
• Gene Alias: AKR6A9; C330022D06Rik; Ckbeta3; K(+) channel subunit beta-3; KCNA3.1B; KCNA3B; Kcnab3; Kcnab4; KV-beta.3; Kv-beta-3; mKv(beta)4; potassium channel, voltage gated shaker-related subfamily A regulatory beta subunit 3; potassium channel, voltage gated subfamily A regulatory beta subunit 3; potassium channel, voltage-dependent, beta-3 subunit; potassium channel, voltage-gated shaker-related subfamily A regulatory beta subunit 3; potassium voltage gated channel, shaker related subfamily, beta member 3; potassium voltage-gated channel subfamily A regulatory beta subunit 3; potassium voltage-gated channel, shaker-related subfamily, beta member 3; RCK beta3; Voltage-gated potassium channel subunit beta-3
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9196
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O43448
• Gene Symbols: KCNAB3
• Immunogen: Recombinant Human KCNAB3. Recombinant protein control fragment (Product #RP-108137).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG