Invitrogen™ KCNE1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5106872

Catalog No. PIPA5106872

Description

Antibody detects endogenous levels of total KCNE1.

Kcne1 is a member of Voltage-gated potassium (Kv) channels that represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. The diverse functions of Kv channels include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. The Kcne1 gene encodes a membrane protein which has sequence similarity to the KCNE1 gene product, a member of the potassium channel, voltage-gated, isk-related subfamily. Kcne1, an intronless gene is deleted in AMME contiguous gene syndrome and may be involved in the cardiac and neurologic abnormalities found in the AMME contiguous gene syndrome. Functionally, Kcne1 is a potassium channel ancillary subunit that is essential for generation of some native K(+) currents by virtue of formation of heteromeric ion channel complex with voltage-gated potassium (Kv) channel pore-forming alpha subunits. Kcne1 also functions as an inhibitory beta-subunit of the repolarizing cardiac potassium ion channel KCNQ1. Diseases associated with KCNE1 include Jervell And Lange-Nielsen Syndrome 2 and Long Qt Syndrome 5.

Specifications

• Antigen: KCNE1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Kcne1
• Gene Alias: cardiac delayed rectifier potassium channel protein; delayed rectifier potassium channel subunit IsK; IKs producing slow voltage-gated potassium channel subunit beta Mink; Isk; JLNS; JLNS 2; JLNS2; KCNE 1; Kcne1; KCNE1 (IsK); LQT 5; LQT2/5; LQT5; m; MGC33114; Minimal potassium channel; mink; mISK; nmf190; potassium (K+) channel protein, slowly activating (Isk); potassium channel, voltage gated subfamily E regulatory beta subunit 1; potassium channel, voltage-gated Isk-related subfamily E regulatory beta subunit 1; potassium voltage-gated channel Shaw-related subfamily member 1; potassium voltage-gated channel subfamily E member 1; potassium voltage-gated channel subfamily E member 1-like; potassium voltage-gated channel subfamily E regulatory subunit 1; potassium voltage-gated channel, Isk-related family, member 1; potassium voltage-gated channel, Isk-related subfamily, member 1; voltage gated potassiun channel accessory subunit
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 16509, 25471, 3753
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P15382, P15383, P23299
• Gene Symbols: Kcne1
• Immunogen: A synthesized peptide derived from human KCNE1(Accession P15382), corresponding to amino acid residues F54-R104.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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