Invitrogen™ KCNH1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA564954

Catalog No. PIPA564954

Description

Immunogen sequence: DSCDSGITKSD LRLDNVGEAR SPQDRSPILA EVKHSFYPIP EQTLQATVLE VRHELKEDIK ALNAKMTNIE KQLSEILRIL TSRRSSQSPQ ELFEISRPQS PES Highest antigen sequence identity to the following orthologs - mouse 91%, rat 92%.

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. KCNH1 encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. KCNH1 is activated at the onset of myoblast differentiation. KCNH1 is highly expressed in brain and in myoblasts. Overexpression of KCNH1 may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of KCNH1 results in two transcript variants encoding distinct isoforms.

Specifications

• Antigen: KCNH1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KCNH1
• Gene Alias: EAG; EAG channel 1; EAG1; ether a go-go; ether-a-go-go potassium channel 1; ether-a-go-go, Drosophila, homolog of; h-eag; hEAG1; Kcnh1; Kv10.1; M-eag; potassium channel, voltage gated eag related subfamily H, member 1; potassium voltage-gated channel subfamily H member 1; potassium voltage-gated channel, subfamily H (eag-related), member 1; r-eag; TMBTS; voltage-gated potassium channel subunit Kv10.1; ZLS1
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3756
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 0.4 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O95259
• Gene Symbols: KCNH1
• Immunogen: Recombinant Human KCNH1. Recombinant protein control fragment (Product #RP-91156).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG