Invitrogen™ KCNK2 Polyclonal Antibody

Catalog No.	Quantity
PIPA5114332	100 μL

Catalog No. PIPA5114332 Supplier Invitrogen™ Supplier No. PA5114332

Description

Rabbit Polyclonal Antibody

KCNK2 Polyclonal Antibody for Flow, IHC (P), Western Blot

TREK-1 is a two-pore-domain background potassium channel expressed throughout the central nervous system. It is opened by polyunsaturated fatty acids and lysophospholipids. As well, it is regulated by various neurotransmitters. It has been shown that alterations in the functioning, regulation, or both of the TREK-1 channel may alter mood. TREK-1 is also activated by volatile anesthetics and has been suggested to be an important target in the action of these drugs. Therefore, this particular K+ channel emerges as a potential innovative target for developing new therapeutic agents for anesthesiology and neurology, such as antidepressants.

Specifications

• Antigen: KCNK2
• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
• Gene: KCNK2
• Gene Accession No.: O95069, P97438, Q920B6
• Gene Alias: A430027H14Rik; AI848635; arachidonic acid sensitive tandem pore domain potassium channel; EMBL:AAU06141.1, ECO:0000312; Ensembl:ENSRNOP00000003684, ECO:0000312; hTREK-1c; hTREK-1e; ion transport membrane protein; K2p2.1; K2P2.1 potassium channel; KCNK2; kcnk2 {ECO:0000312; Kcnk2 potassium channel; outward rectifying potassium channel protein TREK-1; outward rectifying potassium channel protein TREK-1 {ECO:0000250; Potassium channel subfamily K member 2; potassium channel subfamily K member 2 {ECO:0000250; potassium channel subfamily k member 2 variant 1; potassium channel subfamily k member 2 variant 2; potassium channel, subfamily K, member 2; potassium channel, two pore domain subfamily K, member 2; potassium inwardly-rectifying channel, subfamily K, member 2; potassium two pore domain channel subfamily K member 2; PubMed:16248991}; PubMed:24196565}; RGD:621448}; rTREK1d; Stretch-activated potassium channel TREK-1; stretch-activated potassium channel TREK-1 {ECO:0000303; tandem-pore-domain potassium channel TREK-1; TPKC1; TREK; trek 1; TREK1; TREK-1; TREK-1 K(+) channel subunit; TREK-1 K(+) channel subunit {ECO:0000250; TWIK-related potassium channel 1; two pore domain potassium channel TREK-1; two pore domain potassium channel TREK-1 {ECO:0000303; Two pore potassium channel TPKC1; two pore potassium channel TPKC1 {ECO:0000250; two-pore potassium channel 1; UniProtKB:O95069}
• Gene Symbols: KCNK2
• Host Species: Rabbit
• Immunogen: Synthetic peptide within Human KCNK2 aa 7-56.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 16526, 170899, 3776
• Target Species: Human, Mouse, Rat
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov