Invitrogen™ KCNK2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5115452

Catalog No. PIPA5115452

Description

Antibody detects endogenous levels of total KCNK2.

TREK-1 is a two-pore-domain background potassium channel expressed throughout the central nervous system. It is opened by polyunsaturated fatty acids and lysophospholipids. As well, it is regulated by various neurotransmitters. It has been shown that alterations in the functioning, regulation, or both of the TREK-1 channel may alter mood. TREK-1 is also activated by volatile anesthetics and has been suggested to be an important target in the action of these drugs. Therefore, this particular K+ channel emerges as a potential innovative target for developing new therapeutic agents for anesthesiology and neurology, such as antidepressants.

Specifications

• Antigen: KCNK2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KCNK2
• Gene Alias: A430027H14Rik; AI848635; arachidonic acid sensitive tandem pore domain potassium channel; EMBL:AAU06141.1, ECO:0000312; Ensembl:ENSRNOP00000003684, ECO:0000312; hTREK-1c; hTREK-1e; ion transport membrane protein; K2p2.1; K2P2.1 potassium channel; KCNK2; kcnk2 {ECO:0000312; Kcnk2 potassium channel; outward rectifying potassium channel protein TREK-1; outward rectifying potassium channel protein TREK-1 {ECO:0000250; Potassium channel subfamily K member 2; potassium channel subfamily K member 2 {ECO:0000250; potassium channel subfamily k member 2 variant 1; potassium channel subfamily k member 2 variant 2; potassium channel, subfamily K, member 2; potassium channel, two pore domain subfamily K, member 2; potassium inwardly-rectifying channel, subfamily K, member 2; potassium two pore domain channel subfamily K member 2; PubMed:16248991}; PubMed:24196565}; RGD:621448}; rTREK1d; Stretch-activated potassium channel TREK-1; stretch-activated potassium channel TREK-1 {ECO:0000303; tandem-pore-domain potassium channel TREK-1; TPKC1; TREK; trek 1; TREK1; TREK-1; TREK-1 K(+) channel subunit; TREK-1 K(+) channel subunit {ECO:0000250; TWIK-related potassium channel 1; two pore domain potassium channel TREK-1; two pore domain potassium channel TREK-1 {ECO:0000303; Two pore potassium channel TPKC1; two pore potassium channel TPKC1 {ECO:0000250; two-pore potassium channel 1; UniProtKB:O95069}
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 16526, 170899, 3776
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide
• Gene Accession No.: O95069, P97438, Q920B6
• Gene Symbols: KCNK2
• Immunogen: A synthesized peptide derived from human KCNK2(Accession O95069), corresponding to amino acid residues S4-I54.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG