Invitrogen™ KCNK3 Monoclonal Antibody (N374/48)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA527677

Catalog No. PIMA527677

Description

1 μg/mL of MA5-27677 was sufficient for detection of TASK1 Potassium Channel in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 50kDa. Does not cross-react with TASK3. This antibody was formerly sold as clone S374-48.

KCNK3 encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The gene product is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene.

Specifications

• Antigen: KCNK3
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.4
• Gene Accession No.: O14649, O35111, O54912
• Gene Symbols: KCNK3
• Immunogen: Fusion protein amino acids 251-411 (cytoplasmic C-terminus) of rat Acid-sensitive potassium channel protein TASK or TASK1. Mouse: 96% identity (156/161 amino acids identical). Human: 76% identity (163/161 amino acids identical). <30% identity with TASK3.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG2b

• Applications: Immunohistochemistry (PFA fixed), Western Blot, Immunocytochemistry
• Clone: N374/48
• Conjugate: Unconjugated
• Gene: KCNK3
• Gene Alias: acid-sensitive potassium channel protein TASK; acid-sensitive potassium channel protein TASK-1; cardiac potassium channel; cardiac two pore background K(+) channel; Ctbak; cTBAK 1; cTBAK-1; K2p3.1; KCNK3; KCNK9; LOW QUALITY PROTEIN: potassium channel subfamily K member 3; OAT1; Potassium channel subfamily K member 3; potassium channel subfamily K member 3; LOW QUALITY PROTEIN: potassium channel subfamily K member 3; potassium channel, subfamily K, member 3; potassium channel, two pore domain subfamily K, member 3; potassium inwardly-rectifying channel, subfamily K, member 3; potassium two pore domain channel subfamily K member 3; PPH4; rTASK; TASK; TASK 1; TASK1; TASK-1; TASK-1 ion channel receptor; TASK-related potassium channel; TBAK1; TWIK-related acid-sensitive K(+) channel 1; TWIK-related acid-sensitive K+ channel; two P domain potassium channel; two pore K(+) channel KT3.1; Two pore potassium channel KT3.1
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 16527, 29553, 3777
• Content And Storage: -20°C
• Form: Liquid