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Invitrogen™ KCNK3 Monoclonal Antibody (N374/48), PE
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Catalog No. PIMA545704
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Quantity:
100 μg
Catalog No. Quantity
PIMA545704 100 μg
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Catalog No. PIMA545704

Supplier: Invitrogen™ MA545704

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Description

Mouse Monoclonal Antibody

Mouse: 96% identity (156/161 amino acids identical). Human: 76% identity (163/161 amino acids identical). <30% identity with TASK3. 1 μg/mL of MA5-45704 was sufficient for detection of TASK1 Potassium Channel in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 50kDa. Does not cross-react with TASK3. This antibody was formerly sold as clone S374-48.

KCNK3 encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The gene product is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen KCNK3
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone N374/48
Concentration 1 mg/mL
Conjugate PE
Formulation 2.48mM MES, 95.64mM phosphate with 0.5M EDTA and no preservative; pH 7.4
Gene KCNK3
Gene Accession No. O14649, O35111, O54912
Gene Alias acid-sensitive potassium channel protein TASK; acid-sensitive potassium channel protein TASK-1; cardiac potassium channel; cardiac two pore background K(+) channel; Ctbak; cTBAK 1; cTBAK-1; K2p3.1; KCNK3; KCNK9; LOW QUALITY PROTEIN: potassium channel subfamily K member 3; OAT1; Potassium channel subfamily K member 3; potassium channel subfamily K member 3; LOW QUALITY PROTEIN: potassium channel subfamily K member 3; potassium channel, subfamily K, member 3; potassium channel, two pore domain subfamily K, member 3; potassium inwardly-rectifying channel, subfamily K, member 3; potassium two pore domain channel subfamily K member 3; PPH4; rTASK; TASK; TASK 1; TASK1; TASK-1; TASK-1 ion channel receptor; TASK-related potassium channel; TBAK1; TWIK-related acid-sensitive K(+) channel 1; TWIK-related acid-sensitive K+ channel; two P domain potassium channel; two pore K(+) channel KT3.1; Two pore potassium channel KT3.1
Gene Symbols KCNK3
Host Species Mouse
Immunogen Fusion protein amino acids 251-411 (cytoplasmic C-terminus) of rat Acid-sensitive potassium channel protein TASK or TASK1.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16527, 29553, 3777
Target Species Human, Mouse, Rat
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG2b
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