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Invitrogen™ KCNMA1 Polyclonal Antibody
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Catalog No. PIPA5103145
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100 μL
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PIPA5103145 100 μL
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Catalog No. PIPA5103145 Supplier Invitrogen™ Supplier No. PA5103145
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total MaxiK alpha.

Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open.
TRUSTED_SUSTAINABILITY

Specifications

Antigen KCNMA1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Kcnma1
Gene Accession No. Q08460, Q12791, Q62976
Gene Alias 5730414M22Rik; bA205K10.1; big potassium channel alpha subunit; BK channel; BK channel alpha subunit; BKCa; BKCA alpha; BKCA alpha subunit; BKTM; calcium-activated potassium channel alpha subunit; calcium-activated potassium channel subunit alpha-1; calcium-activated potassium channel subunit alpha-1; uncharacterized protein; calcium-activated potassium channel, subfamily M subunit alpha-1; hSlo; K(VCA)alpha; KCa1.1; Kcnma; Kcnma1; KCNMA1b; KCNMA1c; Maxi K channel; maxiK; maxi-K channel HSLO; mSlo; mSlo1; potassium calcium-activated channel subfamily M alpha 1; potassium channel, calcium activated large conductance subfamily M alpha, member 1; potassium large conductance calcium-activated channel, subfamily M, alpha member 1; SAKCA; SLO; slo homolog; slo1; Slo-alpha; Slowpoke homolog; stretch-activated Kca channel
Gene Symbols Kcnma1
Host Species Rabbit
Immunogen A synthesized peptide derived from human KCNMA1(Accession Q12791), corresponding to amino acid residues S778-L828.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16531, 3778, 83731
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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