Invitrogen™ KCNMA1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA595209

Catalog No. PIPA595209

Description

Human KCNMA1 shares 99% amino acid (aa) sequence identity with both mouse and rat KCNMA1. Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: human PC-3 whole cell, human U87 whole cell. IHC: mouse intestine tissue, rat intestine tissue, human lung cancer tissue. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open.

Specifications

• Antigen: KCNMA1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Kcnma1
• Gene Alias: 5730414M22Rik; bA205K10.1; big potassium channel alpha subunit; BK channel; BK channel alpha subunit; BKCa; BKCA alpha; BKCA alpha subunit; BKTM; calcium-activated potassium channel alpha subunit; calcium-activated potassium channel subunit alpha-1; calcium-activated potassium channel subunit alpha-1; uncharacterized protein; calcium-activated potassium channel, subfamily M subunit alpha-1; hSlo; K(VCA)alpha; KCa1.1; Kcnma; Kcnma1; KCNMA1b; KCNMA1c; Maxi K channel; maxiK; maxi-K channel HSLO; mSlo; mSlo1; potassium calcium-activated channel subfamily M alpha 1; potassium channel, calcium activated large conductance subfamily M alpha, member 1; potassium large conductance calcium-activated channel, subfamily M, alpha member 1; SAKCA; SLO; slo homolog; slo1; Slo-alpha; Slowpoke homolog; stretch-activated Kca channel
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 16531, 3778, 83731
• Content And Storage: -20°C
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 500 μg/mL
• Formulation: PBS with 5mg BSA and 0.01mg sodium azide
• Gene Accession No.: Q08460, Q12791, Q62976
• Gene Symbols: Kcnma1
• Immunogen: E.coli-derived human KCNMA1 recombinant protein (Position: K124-Q467).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG