Invitrogen™ KCNMB1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA587724

Catalog No. PIPA587724

Description

Immunogen sequence: TYYILVTTVL PLYQKSVWTQ ESKCHLIETN IRDQEELKGK KVPQYPCLWV NVSAAGRWAV LYHTEDTRDQ NQQ; Positive Samples: U-87MG, THP-1, BxPC-3; Cellular Location: Membrane, Multi-pass membrane protein.

Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open. Maxi K+ beta is the target for possible therapeutics because of its role in blood flow and blood pressure regulation.

Specifications

• Antigen: KCNMB1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KCNMB1
• Gene Alias: big potassium channel beta subunit 1; BK channel beta subunit; BK channel beta subunit 1; BK channel subunit beta-1; BKbeta; BKbeta1; calcium-activated potassium channel beta subunit; calcium-activated potassium channel subunit beta; Calcium-activated potassium channel subunit beta-1; calcium-activated potassium channel, subfamily M subunit beta-1; Charybdotoxin receptor subunit beta-1; hbeta1; hslo-beta; K(VCA)beta; k(VCA)beta-1; Kcnmb1; large conductance Ca2+-activated K+ channel beta 1 subunit; maxi K channel subunit beta-1; MaxiK channel beta-subunit 1; potassium calcium-activated channel subfamily M regulatory beta subunit 1; potassium channel subfamily M regulatory beta subunit 1; potassium large conductance calcium-activated channel, subfamily M, beta member 1; slo-beta; slo-beta-1; slowpoke-beta
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3779
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 2.21 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q16558
• Gene Symbols: KCNMB1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 30-102 of human KCNMB1 (NP_0041281).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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