Invitrogen™ KCNQ1 Polyclonal Antibody

Catalog No.	Quantity
PIPA596082	100 μL

Catalog No. PIPA596082 Supplier Invitrogen™ Supplier No. PA596082

Description

Rabbit Polyclonal Antibody

Immunogen sequence: TAWRCYAAEN PDSSTWKIYI RKAPRSHTLL SPSPKPKKSV VVKKKKFKLD KDNGVTPGEK MLTVPHITCD PPEERRLDHF SVDGYDSSVR KSPTLLEVSM PHFMRTNSFA EDLDLEGETL LTPITHISQL REHHRATIKV IRRMQYFVAK KKFQQARKPY DVRDVIEQYS QGHLNLMVRI KELQRRLDQS IGKPSLFISV SEKSKDRGSN TIGARLNRVE DKVTQLDQRL ALITDMLHQL LSLHGGSTPG SGGPPREGGA HITQPCGSGG SVDPELFLPS NTLPTYEQLT VPRRGPDEGS; Positive Samples: HT-29, SW620, Mouse kidney, BT-474; Cellular Location: Cell membrane, Cytoplasmic vesicle membrane, Multi-pass membrane protein.

Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles and other excitable cells. A specific K+ channel, comprised of an alpha subunit KCNQ1 and a beta subunit KCNE1, a small protein which spans the membrane only once, is predominantly expressed in the heart and in the cochlea, and is responsible for regulating the slow, depolarization-activated potassium current. Mutations in the genes encoding for KCNQ1 and KCNE1 lead to cardiac disease because they directly impair electrical signaling, and mutations in KCNQ4 are implicated in the onset of deafness. KCNQ proteins, including KCNQ1 and KCNQ4, characteristically contain six transmembrane domains and function as tetramers. KCNQ4 forms heteromeric channels with KCNQ3 and is expressed in several tissues, including the cochlea, where it is present in outer hair cells.

Specifications

• Antigen: KCNQ1
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Concentration: 0.26 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: KCNQ1
• Gene Accession No.: P51787, P97414, Q9Z0N7
• Gene Alias: ATFB1; ATFB3; AW559127; FLJ26167; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; JLNS1; KCNA8; KCNA9; Kcnq1; kidney and cardiac voltage dependend K+ channel; KQT-like 1; Kv1.9; Kv7.1; KVLQT1; LQT; LQT1; mutant potassium voltage-gated channel KQT-like subfamily member 1; potassium channel, voltage gated KQT-like subfamily Q, member 1; potassium channel, voltage-gated KQT-like subfamily Q, member 1; potassium voltage-gated channel subfamily KQT member 1; potassium voltage-gated channel subfamily Q member 1; potassium voltage-gated channel, KQT-like subfamily, member 1; potassium voltage-gated channel, subfamily Q, member 1; RWS; slow delayed rectifier channel subunit; SQT2; voltage-gated potassium channel subunit Kv7.1; WRS
• Gene Symbols: KCNQ1
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 250-549 of human KCNQ1 (NP_8614631).
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 16535, 3784, 84020
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG