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Invitrogen™ KCNQ4 Monoclonal Antibody (N43/6), FITC
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Catalog No. PIMA545412
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100 μg
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Catalog No. Quantity
PIMA545412 100 μg
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Catalog No. PIMA545412 Supplier Invitrogen™ Supplier No. MA545412
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Description

Mouse Monoclonal Antibody

1 μg/mL of MA5-45412 was sufficient for detection of KCNQ4 in 10 μg of COS-1 cell lysate transiently expressing KCNQ4 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 77kDa.

The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2, an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen KCNQ4
Applications Immunohistochemistry (Paraffin), Immunohistochemistry (PFA fixed), Western Blot, Immunocytochemistry, Microarray
Classification Monoclonal
Clone N43/6
Concentration 1 mg/mL
Conjugate FITC
Formulation PBS, 9.1mM sodium bicarbonate with 640.91mM DMSO, 136.36mM ethanolamine and no preservative; pH 7.4
Gene KCNQ4
Gene Accession No. P56696, Q9JK96, Q9JK97
Gene Alias DFNA 2; DFNA2; DFNA2A; KCNQ 4; KCNQ4; KQT like 4; KQT-like 4; KV7.4; LOW QUALITY PROTEIN: potassium voltage-gated channel subfamily KQT member 4; potassium channel KQT-like 4; potassium channel subunit alpha KvLQT4; potassium channel, voltage gated KQT-like subfamily Q, member 4; potassium channel, voltage-gated KQT-like subfamily Q, member 4; potassium voltage-gated channel KQT-like protein 4; potassium voltage-gated channel KQT-like subfamily member 4; potassium voltage-gated channel subfamily KQT member 4; potassium voltage-gated channel subfamily Q member 4; potassium voltage-gated channel, KQT-like subfamily, member 4; potassium voltage-gated channel, subfamily Q, member 4; voltage-gated potassium channel subunit Kv7.4
Gene Symbols KCNQ4
Host Species Mouse
Immunogen Fusion protein amino acids 2-77 of human KCNQ4.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 298496, 60613, 9132
Target Species Human, Mouse, Rat
Content And Storage 4°C, store in dark
Product Type Antibody
Form Liquid
Isotype IgG1
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