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Invitrogen™ KCNQ4 Polyclonal Antibody
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Catalog No. PIPA5119709
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100 μL
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PIPA5119709 100 μL
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Catalog No. PIPA5119709 Supplier Invitrogen™ Supplier No. PA5119709
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Description

Rabbit Polyclonal Antibody

Positive Control: Rat kidney tissue lysates, 293T, rat smooth muscle tissue, mouse brain tissue, K562. Subcellular Location: Cell membrane, Membrane.

The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2, an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen KCNQ4
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
Gene KCNQ4
Gene Accession No. P56696, Q9JK96, Q9JK97
Gene Alias DFNA 2; DFNA2; DFNA2A; KCNQ 4; KCNQ4; KQT like 4; KQT-like 4; KV7.4; LOW QUALITY PROTEIN: potassium voltage-gated channel subfamily KQT member 4; potassium channel KQT-like 4; potassium channel subunit alpha KvLQT4; potassium channel, voltage gated KQT-like subfamily Q, member 4; potassium channel, voltage-gated KQT-like subfamily Q, member 4; potassium voltage-gated channel KQT-like protein 4; potassium voltage-gated channel KQT-like subfamily member 4; potassium voltage-gated channel subfamily KQT member 4; potassium voltage-gated channel subfamily Q member 4; potassium voltage-gated channel, KQT-like subfamily, member 4; potassium voltage-gated channel, subfamily Q, member 4; voltage-gated potassium channel subunit Kv7.4
Gene Symbols KCNQ4
Host Species Rabbit
Immunogen Synthetic peptide within mouse KCNQ4 aa 580-640.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 298496, 60613, 9132
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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