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Invitrogen™ KCNQ5 Polyclonal Antibody
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Catalog No. PIPA5110817
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100 μL
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PIPA5110817 100 μL
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Catalog No. PIPA5110817 Supplier Invitrogen™ Supplier No. PA5110817
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: LALASFQIPP FECEQTSDYQ SPVDSKDLSG SAQNSGCLSR STSANISRGL QFILTPNEFS AQTFYALSPT MHSQATQVPI SQSDGSAVAA TNTIANQINT APKPAAPTTL QIPPPL Highest antigen sequence indentity to the following orthologs: Rat - 88%, Mouse - 91%.

KCNQs are members of the voltage-dependent non-inactivating potassium channel family. Currently there are five known KNCQs (KCNQ1-5) found in the central nervous system. Studies have shown that KCNQ3 and KCNQ5 form heteromultimers that, when formed, substantially increase the M-current. Inhibition of M-current controls neuron excitability throughout the nervous system as well as the responsiveness to synaptic inputs. Genetic mutations in these proteins have been linked to disorders such as benign familial neonatal convulsions (BFNC), deafness, neuropathic pain and epilepsy. Voltage-dependent potassium channels are key regulators of the resting membrane potential and modulate the excitability of electrically active cells. The channels are usually tetrameric and can interact with auxiliary subunits that enhance or modify currents mediated by the pore-forming subunits.
TRUSTED_SUSTAINABILITY

Specifications

Antigen KCNQ5
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.10 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene KCNQ5
Gene Accession No. Q9NR82
Gene Alias 7730402H11; 9230107O05Rik; AA589396; D1Mgi1; KCNQ5; Kcnq5l; KQT-like 5; Kv7.5; KvLQT5; potassium channel protein; potassium channel subunit alpha KvLQT5; potassium channel, voltage gated KQT-like subfamily Q, member 5; potassium channel, voltage-gated KQT-like subfamily Q, member 5; potassium voltage-gated channel subfamily KQT member 5; potassium voltage-gated channel subfamily Q member 5; potassium voltage-gated channel, KQT-like subfamily, member 5; potassium voltage-gated channel, subfamily Q, member 5; rCG_43583; voltage-gated potassium channel subunit Kv7.5; voltage-gated potassium channel type Kv7.5
Gene Symbols KCNQ5
Host Species Rabbit
Immunogen Recombinant Protein corresonding to Human KCNQ5. Recombinant protein control fragment (Product #RP-91239).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 56479
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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