Invitrogen™ KCNT2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA562348

Catalog No. PIPA562348

Description

Immunogen sequence: GIYRTESQKL TTSESQISIS VEEWEDTKDS KEQGHHRSNH RNSTSSDQSD HPLLRR Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 93%.

Kcnt2 calcium (Ca2+) -activated potassium channels (KCa) are a group of 6/7-TM ion channels that selectively transport K+ ions across biological membranes. KCa channels are broadly classified into three subtypes: SK, IK and BK channels (small, intermediate and big conductance). Kcnt2 is an outward rectifying potassium channel, and produces rapidly activating outward rectifier K(+) currents. Kcnt2 is activated by high intracellular sodium and chloride levels. Further, Kcnt2 channel activity is inhibited by ATP and by inhalation anesthetics, such as isoflurane. Functionally, Kcnt2 is inhibited upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1.

Specifications

• Antigen: KCNT2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Kcnt2
• Gene Alias: E330038N15Rik; KCa4.2; Kcnt2; Potassium channel subfamily T member 2; potassium channel, sodium activated subfamily T, member 2; potassium channel, sodium-activated subfamily T, member 2; potassium channel, subfamily T, member 2; potassium sodium-activated channel subfamily T member 2; sequence like an intermediate conductance potassium channel subunit; SLICK; SLO2.1; sodium- and chloride-activated ATP-sensitive potassium channel; sodium and chloride-activated ATP-sensitive potassium channel Slo2.1; sodium- and chloride-activated ATP-sensitive potassium channel subunit; sodium-and chloride-activated ATP-sensitive potassium channel (SLICK)
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 343450
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q6UVM3
• Gene Symbols: Kcnt2
• Immunogen: Recombinant protein corresponding to Human KCNT2. Recombinant protein control fragment (Product #RP-101419).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov