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Invitrogen™ KCTD19 Polyclonal Antibody
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Catalog No. PIPA561929
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100 μL
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Catalog No. Quantity
PIPA561929 100 μL
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Catalog No. PIPA561929 Supplier Invitrogen™ Supplier No. PA561929
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: GVILKVTHPP VVGSDGFCMF FEDSIIYTTE MDNLRHTTPT ASPQPQEVTF LSFSLSWEEM FYAQKCHCFL ADIIMDSIRQ KDPKAITAKV VSLANRLWTL HISPKQF Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 88%.

The KCTD19 (Potassium Channel Tetramerization Domain Containing 19) gene encodes a protein that plays a crucial role in meiotic chromosome organization and male fertility. KCTD19 is located on chromosome 5 in humans. The protein is known to interact with zinc finger protein 541 (ZFP541) and histone deacetylase 1 (HDAC1), highlighting its role in chromatin organization and transcription regulation during meiosis. Mutations or loss-of-function variants in KCTD19 have been implicated in non-obstructive azoospermia (NOA) and male infertility, as evidenced by studies in both human and mouse models. The gene's function in regulating the individualization of meiotic chromosomes is critical, and disruptions can lead to severe meiotic defects and spermatogenic failure.
TRUSTED_SUSTAINABILITY

Specifications

Antigen KCTD19
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration Lot-Specific
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene KCTD19
Gene Accession No. Q17RG1
Gene Alias 4922504H04Rik; BTB/POZ domain-containing protein KCTD19; KCTD19; potassium channel tetramerisation domain containing 19; potassium channel tetramerization domain containing 19; RGD1561326; testicular tissue protein Li 101
Gene Symbols KCTD19
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human KCTD19. Recombinant protein control fragment (Product #RP-98755).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 146212
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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