Invitrogen™ KCTD19 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA532114

Catalog No. PIPA532114

Description

Recommended positive controls: U87-MG, SK-N-SH. Predicted reactivity: Mouse (96%), Rat (97%), Bovine (97%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The KCTD19 (Potassium Channel Tetramerization Domain Containing 19) gene encodes a protein that plays a crucial role in meiotic chromosome organization and male fertility. KCTD19 is located on chromosome 5 in humans. The protein is known to interact with zinc finger protein 541 (ZFP541) and histone deacetylase 1 (HDAC1), highlighting its role in chromatin organization and transcription regulation during meiosis. Mutations or loss-of-function variants in KCTD19 have been implicated in non-obstructive azoospermia (NOA) and male infertility, as evidenced by studies in both human and mouse models. The gene's function in regulating the individualization of meiotic chromosomes is critical, and disruptions can lead to severe meiotic defects and spermatogenic failure.

Specifications

• Antigen: KCTD19
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KCTD19
• Gene Alias: 4922504H04Rik; BTB/POZ domain-containing protein KCTD19; KCTD19; potassium channel tetramerisation domain containing 19; potassium channel tetramerization domain containing 19; RGD1561326; testicular tissue protein Li 101
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 146212, 279499
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q17RG1, Q562E2
• Gene Symbols: KCTD19
• Immunogen: Recombinant protein encompassing a sequence within the N-terminus region of human KCTD19. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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