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Invitrogen™ KCTD4 Monoclonal Antibody (2C8)
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Catalog No. PIMA523295
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100 μg
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Catalog No. Quantity
PIMA523295 100 μg
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Catalog No. PIMA523295 Supplier Invitrogen™ Supplier No. MA523295
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Description

Mouse Monoclonal Antibody

Peptide Sequence: MERKINRREK EKEYEGKHNS LEDTDQGKNC KSTLMTLNVG GYLYITQKQT LTKYPDTFLE GIVNGKILCP FDADGHYFID RDGLLFRHVL NFLRNGELLL PEGFRENQLL AQEAEFFQLK GLAEEVKSRW EKEQLTPRET TFLEITDNHD RSQGLRIFCN APDFISKIKS RIVLVSKSRL DGFPEEFSIS SNIIRFKYFI KSENGTRLVL KEDNTFVCTL ETLKFEAIMM ALKCGFRLLT SLDCSKGSIV HSDALHFIK.

The KCTD4 (Potassium Channel Tetramerization Domain Containing 4) gene encodes a protein involved in various cellular processes, including the regulation of calcium homeostasis and modulation of fibroblast activity. KCTD4 interacts with chloride intracellular channel 1 (CLIC1) to disrupt calcium homeostasis, leading to increased fibronectin secretion, which activates fibroblasts via paracrine signaling. This activation can promote cancer cell invasion through matrix metalloproteinase 24 (MMP24) signaling. The interaction between KCTD4 and CLIC1 presents a potential target for therapeutic strategies, as inhibition of this interaction has been shown to significantly suppress cancer metastasis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen KCTD4
Applications ELISA, Western Blot
Classification Monoclonal
Clone 2C8
Concentration 1.0 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative; pH 7.4
Gene KCTD4
Gene Accession No. Q8WVF5
Gene Alias bA321C24.3; BTB/POZ domain-containing protein KCTD4; KCTD4; potassium channel tetramerisation domain containing 4; potassium channel tetramerization domain containing 4
Gene Symbols KCTD4
Host Species Mouse
Immunogen KCTD4 (AAH18063, 1 a.a. ~ 259 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification Method Affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 386618
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2b κ
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