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Invitrogen™ KCTD4 Polyclonal Antibody
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Catalog No. PIPA559272
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100 μL
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PIPA559272 100 μL
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Catalog No. PIPA559272 Supplier Invitrogen™ Supplier No. PA559272
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: LNFLRNGELL LPEGFRENQL LAQEAEFFQL KGLAEEVKSR WEKEQLTPRE TTFLEITDNH DRSQGLRIFC NAPDF Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 99%.

The KCTD4 (Potassium Channel Tetramerization Domain Containing 4) gene encodes a protein involved in various cellular processes, including the regulation of calcium homeostasis and modulation of fibroblast activity. KCTD4 interacts with chloride intracellular channel 1 (CLIC1) to disrupt calcium homeostasis, leading to increased fibronectin secretion, which activates fibroblasts via paracrine signaling. This activation can promote cancer cell invasion through matrix metalloproteinase 24 (MMP24) signaling. The interaction between KCTD4 and CLIC1 presents a potential target for therapeutic strategies, as inhibition of this interaction has been shown to significantly suppress cancer metastasis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen KCTD4
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene KCTD4
Gene Accession No. Q8WVF5
Gene Alias bA321C24.3; BTB/POZ domain-containing protein KCTD4; KCTD4; potassium channel tetramerisation domain containing 4; potassium channel tetramerization domain containing 4
Gene Symbols KCTD4
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human KCTD4. Recombinant protein control fragment (Product #RP-98002).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 386618
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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