Invitrogen™ KCTD4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA531295

Catalog No. PIPA531295

Description

Recommended positive controls: A431. Predicted reactivity: Human (99%), Mouse (97%), Rat (96%), Chicken (86%), Bovine (98%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The KCTD4 (Potassium Channel Tetramerization Domain Containing 4) gene encodes a protein involved in various cellular processes, including the regulation of calcium homeostasis and modulation of fibroblast activity. KCTD4 interacts with chloride intracellular channel 1 (CLIC1) to disrupt calcium homeostasis, leading to increased fibronectin secretion, which activates fibroblasts via paracrine signaling. This activation can promote cancer cell invasion through matrix metalloproteinase 24 (MMP24) signaling. The interaction between KCTD4 and CLIC1 presents a potential target for therapeutic strategies, as inhibition of this interaction has been shown to significantly suppress cancer metastasis.

Specifications

• Antigen: KCTD4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KCTD4
• Gene Alias: bA321C24.3; BTB/POZ domain-containing protein KCTD4; KCTD4; potassium channel tetramerisation domain containing 4; potassium channel tetramerization domain containing 4
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 386618
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q8WVF5
• Gene Symbols: KCTD4
• Immunogen: Recombinant protein encompassing a sequence within the center region of human KCTD4. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG