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Invitrogen™ KCTD4 Polyclonal Antibody
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Catalog No. PIPA531295
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100 μL
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Catalog No. Quantity
PIPA531295 100 μL
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Catalog No. PIPA531295 Supplier Invitrogen™ Supplier No. PA531295
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: A431. Predicted reactivity: Human (99%), Mouse (97%), Rat (96%), Chicken (86%), Bovine (98%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The KCTD4 (Potassium Channel Tetramerization Domain Containing 4) gene encodes a protein involved in various cellular processes, including the regulation of calcium homeostasis and modulation of fibroblast activity. KCTD4 interacts with chloride intracellular channel 1 (CLIC1) to disrupt calcium homeostasis, leading to increased fibronectin secretion, which activates fibroblasts via paracrine signaling. This activation can promote cancer cell invasion through matrix metalloproteinase 24 (MMP24) signaling. The interaction between KCTD4 and CLIC1 presents a potential target for therapeutic strategies, as inhibition of this interaction has been shown to significantly suppress cancer metastasis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen KCTD4
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
Gene KCTD4
Gene Accession No. Q8WVF5
Gene Alias bA321C24.3; BTB/POZ domain-containing protein KCTD4; KCTD4; potassium channel tetramerisation domain containing 4; potassium channel tetramerization domain containing 4
Gene Symbols KCTD4
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human KCTD4. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 386618
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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