Invitrogen™ KDEL Receptor Pan Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5101011

Catalog No. PIPA5101011

Description

Antibody detects endogenous levels of total KDEL.

Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by this gene was the first member of the family to be identified, and it encodes a protein structurally and functionally similar to the yeast ERD2 gene product.

Specifications

• Antigen: KDEL Receptor Pan
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KDELR3
• Gene Alias: (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2; 1110007A14Rik; 8030486F04Rik; AI173274; AW215843; BEST:CK00230; CG5183; CG5183-PA; CG5183-PB; CG5183-PC; CK00230; Dmel\CG5183; Dmel_CG5183; dmErd2; ELP-1; ER lumem protein retaining receptor 2; ER lumen protein retaining receptor; ER lumen protein retaining receptor 1; ER lumen protein retaining receptor 2; ER lumen protein retaining receptor 3; ER lumen protein-retaining receptor; ER lumen protein-retaining receptor 1; ER lumen protein-retaining receptor 2; ER lumen protein-retaining receptor 3; ERD2; Erd2.1; ERD2.2; ERD23; ERD2L3; ERD-2-like protein; ERD2-like protein 1; ergr15; HDEL; hypothetical protein; I79_001653; I79_020931; I79_023963; KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1; KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2; KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3; KDEL endoplasmic reticulum protein retention receptor 1; KDEL endoplasmic reticulum protein retention receptor 2; KDEL endoplasmic reticulum protein retention receptor 2 L homeolog; KDEL endoplasmic reticulum protein retention receptor 3; KDEL receptor; KDEL receptor 1; KDEL receptor 2; KDEL receptor 3; KDEL receptor-like protein; KDELR; Kdelr1; Kdelr2; kdelr2.L; KDELR3; KDEL-receptor; KdelR-PA; KdelR-PB; KdelR-PC; l(2)31Em; l(2)k00311; lethal (2) 31Em; PM23; Putative MAPK-activating protein PM23; RCJMB04_8l23; Unknown (protein for MGC:128955); XELAEV_18045328mg
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 105785, 10945, 11014, 11015, 304290, 315131, 361577, 66913, 68137
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: O43731, P24390, P33947, Q569A6, Q5U305, Q8R1L4, Q99JH8, Q9CQM2
• Gene Symbols: KDELR1, KDELR2, KDELR3
• Immunogen: A synthesized peptide derived from human KDELR1(Accession P24390), corresponding to amino acid residues N89-S139.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov