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Invitrogen™ KDELR2 Polyclonal Antibody
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Catalog No. PA549559
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PA549559 100 μL
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Catalog No. PA549559 Supplier Invitrogen™ Supplier No. PA549559
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Description

Rabbit Polyclonal Antibody

KDELR2 Polyclonal Antibody for ICC/IF, Western Blot

Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83% identical to the KDELR1 gene product. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008].
TRUSTED_SUSTAINABILITY

Specifications

Antigen KDELR2
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.09% sodium azide; pH 7.4
Gene KDELR2
Gene Accession No. P33947, Q5U305, Q9CQM2
Gene Alias (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2; 1110007A14Rik; ELP1; ELP-1; ER lumen protein retaining receptor 2; ER lumen protein-retaining receptor 2; ERD2.2; ERD22; ERD-2-like protein; ERD2-like protein 1; KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2; KDEL endoplasmic reticulum protein retention receptor 2; KDEL receptor 2; Kdelr2
Gene Symbols KDELR2
Host Species Rabbit
Immunogen synthetic peptide corresponding to 90-125aa of human ERD22.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11014, 304290, 66913
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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