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Invitrogen™ KDELR2 Polyclonal Antibody
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Catalog No. PIPA553424
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PIPA553424 100 μL
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Catalog No. PIPA553424 Supplier Invitrogen™ Supplier No. PA553424
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: YSRERSSVCQ HKCQRPSPAS VLQGARTEFL PQQRHKMLDT ENQKLNSFVA DSHQWLCK Highest antigen sequence identity to the following orthologs: Mouse - 29%, Rat - 28%.

Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83% identical to the KDELR1 gene product. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008].
TRUSTED_SUSTAINABILITY

Specifications

Antigen KDELR2
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene KDELR2
Gene Accession No. P33947
Gene Alias (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2; 1110007A14Rik; ELP1; ELP-1; ER lumen protein retaining receptor 2; ER lumen protein-retaining receptor 2; ERD2.2; ERD22; ERD-2-like protein; ERD2-like protein 1; KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2; KDEL endoplasmic reticulum protein retention receptor 2; KDEL receptor 2; Kdelr2
Gene Symbols KDELR2
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human KDELR2. Recombinant protein control fragment (Product #RP-91149).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11014
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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