Invitrogen™ KDELR2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA553424

Catalog No. PIPA553424

Description

Immunogen sequence: YSRERSSVCQ HKCQRPSPAS VLQGARTEFL PQQRHKMLDT ENQKLNSFVA DSHQWLCK Highest antigen sequence identity to the following orthologs: Mouse - 29%, Rat - 28%.

Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83% identical to the KDELR1 gene product. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008].

Specifications

• Antigen: KDELR2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KDELR2
• Gene Alias: (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2; 1110007A14Rik; ELP1; ELP-1; ER lumen protein retaining receptor 2; ER lumen protein-retaining receptor 2; ERD2.2; ERD22; ERD-2-like protein; ERD2-like protein 1; KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2; KDEL endoplasmic reticulum protein retention receptor 2; KDEL receptor 2; Kdelr2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11014
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P33947
• Gene Symbols: KDELR2
• Immunogen: Recombinant protein corresponding to Human KDELR2. Recombinant protein control fragment (Product #RP-91149).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov