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Invitrogen™ KDELR3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA567422

Catalog No. PIPA567422


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Description

Description

Immunogen sequence: YMIYGKFRKTF DSENDTFRLE F Highest antigen sequence identity to the following orthologs - mouse 91%, rat 91%.

This gene encodes a member of the KDEL endoplasmic reticulum protein retention receptor family. Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR3 was the third member of the family to be identified. Alternate splicing results in multiple transcript variants.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

KDELR3
Polyclonal
Unconjugated
KDELR3
AI173274; ER lumen protein retaining receptor 3; ER lumen protein-retaining receptor 3; ERD23; ERD2L3; KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3; KDEL endoplasmic reticulum protein retention receptor 3; KDEL receptor 3; Kdelr3
Rabbit
Antigen affinity chromatography
RUO
11015
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Immunocytochemistry
0.05 mg/mL
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
O43731
KDELR3
Recombinant Human KDEL Receptor Pan. Recombinant protein control fragment (Product #RP-108083).
100 μL
Primary
Human
Antibody
IgG
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