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Invitrogen™ KDM1B Monoclonal Antibody (5E10C1)
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Catalog No. PIMA531624
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100 μL
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Catalog No. Quantity
PIMA531624 100 μL
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Catalog No. PIMA531624 Supplier Invitrogen™ Supplier No. MA531624
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Description

Mouse Monoclonal Antibody

MA5-31624 has been tested in indirect ELISA.

The KDM1B gene, also known as lysine demethylase 1B, or LSD2/AOF1, encodes a histone demethylase that specifically targets H3K4me1/2 marks, which are critical for regulating gene expression. KDM1B is an epigenetic modifier that plays a pivotal role in modulating chromatin structure and, consequently, gene transcription. Unlike its homolog KDM1A, KDM1B associates mainly with the gene bodies of actively transcribed genes rather than promoters, indicating its unique role in transcriptional regulation. KDM1B is implicated in various physiological processes and pathophysiological conditions, including tumor progression where it enhances somatic cell reprogramming and promotes the enrichment of tumor stem cells. Its demethylation activity against histones H3K4 and H3K9 underscores its influence on gene silencing and activation pathways, marking it as a significant target in cancer research and potential therapeutic interventions. Understanding the structural and functional nuances of KDM1B contributes to broader insights into epigenetic regulation mechanisms and their implications in disease states.
TRUSTED_SUSTAINABILITY

Specifications

Antigen KDM1B
Applications ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 5E10C1
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% sodium azide
Gene KDM1B
Gene Accession No. Q8NB78
Gene Alias 4632428N09Rik; AI482520; amine oxidase (flavin containing) domain 1; amine oxidase, flavin containing 1; Aof1; bA204B7.3; C6orf193; dJ298J15.2; Flavin-containing amine oxidase domain-containing protein 1; KDM1B; LSD2; lysine (K)-specific demethylase 1B; lysine demethylase 1B; lysine-specific histone demethylase 1B; Lysine-specific histone demethylase 2
Gene Symbols KDM1B
Host Species Mouse
Immunogen Purified recombinant fragment of human AOF1 (AA: 6-129) expressed in E. coli.
Purification Method Protein G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 221656
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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