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Invitrogen™ KDM1B Recombinant Rabbit Monoclonal Antibody (5M3W2)
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Catalog No. PIMA538021
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100 μL
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PIMA538021 100 μL
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Catalog No. PIMA538021 Supplier Invitrogen™ Supplier No. MA538021
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Description

Rabbit Recombinant Monoclonal Antibody

Positive Samples: HeLa, HCT116, HepG2 Immunogen sequence: MATPRGRTKK KASFDHSPDS LPLRSSGRQA KKKATETTDE DEDGGSEKKY RKCEKAGCTA TCPVCFASAS ERCAKNGYTS RWYHLSCGEH FCNECFDHYY.

The KDM1B gene, also known as lysine demethylase 1B, or LSD2/AOF1, encodes a histone demethylase that specifically targets H3K4me1/2 marks, which are critical for regulating gene expression. KDM1B is an epigenetic modifier that plays a pivotal role in modulating chromatin structure and, consequently, gene transcription. Unlike its homolog KDM1A, KDM1B associates mainly with the gene bodies of actively transcribed genes rather than promoters, indicating its unique role in transcriptional regulation. KDM1B is implicated in various physiological processes and pathophysiological conditions, including tumor progression where it enhances somatic cell reprogramming and promotes the enrichment of tumor stem cells. Its demethylation activity against histones H3K4 and H3K9 underscores its influence on gene silencing and activation pathways, marking it as a significant target in cancer research and potential therapeutic interventions. Understanding the structural and functional nuances of KDM1B contributes to broader insights into epigenetic regulation mechanisms and their implications in disease states.
TRUSTED_SUSTAINABILITY

Specifications

Antigen KDM1B
Applications ELISA, Western Blot
Classification Recombinant Monoclonal
Clone 5M3W2
Concentration 0.6 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene KDM1B
Gene Accession No. Q8NB78
Gene Alias 4632428N09Rik; AI482520; amine oxidase (flavin containing) domain 1; amine oxidase, flavin containing 1; Aof1; bA204B7.3; C6orf193; dJ298J15.2; Flavin-containing amine oxidase domain-containing protein 1; KDM1B; LSD2; lysine (K)-specific demethylase 1B; lysine demethylase 1B; lysine-specific histone demethylase 1B; Lysine-specific histone demethylase 2
Gene Symbols KDM1B
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 1-100 of human LSD2/KDM1B/AOF1 (NP_6945873).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 221656
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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