Invitrogen™ KDM5A Recombinant Rabbit Monoclonal Antibody (5B10P1)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA535572

Catalog No. PIMA535572

Description

Immunogen sequence: HAYSSASKSC SQGSSTPRKQ PRKSPLVPRS LEPPVLELSP GAKAQLEELM MVGDLLEVSL DETQHIWRIL QATHPPSEDR FLHIMEDDSM EEKPLKVKGK DSSEKKRKRK LEKVEQLFGE GKQKSKELKK MDKPRKKKLK LGADKSKELN KLAKKLAKEE ERKKKKEKAA AAKVELVKES TEKKREKKVL DIPSKYDWSG AEESDDENAV CAAQNCQRPC KDKVDWVQCD GGCDEWFHQV CVGVSPEMAE NEDYICINCA KKQGPVSPGP APPPSFIMSY KLPMEDLKET S.

UPF3B is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The protein is one of two functional homologs to yeast Upf3p. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctionsThis gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: KDM5A
• Classification: Recombinant Monoclonal
• Concentration: 2 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P29375, Q3UXZ9
• Gene Symbols: KDM5A
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1400-1690 of human KDM5A (P29375).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: ChIP Assay, ELISA, Immunoprecipitation, Western Blot
• Clone: 5B10P1
• Conjugate: Unconjugated
• Gene: KDM5A
• Gene Alias: AA409370; C76986; histone demethylase JARID1A; JARID1A; jumonji, AT rich interactive domain 1A (Rbp2 like); Jumonji, AT rich interactive domain 1A (RBP2-like); jumonji/ARID domain-containing protein 1A; Kdm5a; lysine (K)-specific demethylase 5A; lysine demethylase 5A; lysine-specific demethylase 5A; Rbbp2; RBBP-2; RBP2; retinoblastoma binding protein 2; retinoblastoma-binding protein 2
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 214899, 312678, 5927
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid