Invitrogen™ KDM5A Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5121081

Catalog No. PIPA5121081

Description

Positive test controls include: Jurkat, HeLa, MCF7. The target is usually found in the following locations: Nucleus, nucleolus.

UPF3B is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The protein is one of two functional homologs to yeast Upf3p. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctionsThis gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: KDM5A
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KDM5A
• Gene Alias: AA409370; C76986; histone demethylase JARID1A; JARID1A; jumonji, AT rich interactive domain 1A (Rbp2 like); Jumonji, AT rich interactive domain 1A (RBP2-like); jumonji/ARID domain-containing protein 1A; Kdm5a; lysine (K)-specific demethylase 5A; lysine demethylase 5A; lysine-specific demethylase 5A; Rbbp2; RBBP-2; RBP2; retinoblastoma binding protein 2; retinoblastoma-binding protein 2
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 312678, 5927
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ChIP Assay, ELISA, Immunoprecipitation, Western Blot
• Concentration: 0.66 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P29375
• Gene Symbols: KDM5A
• Immunogen: Recombinant protein of human KDM5A.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG