Learn More
Invitrogen™ KDM5B Monoclonal Antibody (CL1147)
Mouse Monoclonal Antibody
Supplier: Invitrogen™ MA524627
Description
Immunogen sequence: DGINSLERKL KRRLEREGLS SERWERVKKM RTPKKKKIKL SHPKDMNNFK LERERSYELV RSAETHSLPS DTSYSEQEDS E Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 91%. Binds to an epitope located within the peptide sequence SERWERVKKMRTPKK as determined by overlapping synthetic peptides.
KDM5B is a histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. It does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. KDM5B demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. It acts as a transcriptional corepressor for FOXG1B and PAX9. It favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, KDM5B may act as a tumor suppressor for melanoma.
Specifications
KDM5B | |
Monoclonal | |
1 mg/mL | |
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
Q9UGL1 | |
KDM5B | |
Recombinant protein corresponding to Human KDM5B. | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG1 |
Western Blot | |
CL1147 | |
Unconjugated | |
KDM5B | |
2010009J12Rik; 2210016I17Rik; AW556288; cancer/testis antigen 31; CT31; D1Ertd202e; Histone demethylase JARID1B; Jarid1b; jumonji, AT rich interactive domain 1B; jumonji, AT rich interactive domain 1B (Rbp2 like); Jumonji, AT rich interactive domain 1B (RBP2-like); jumonji/ARID domain-containing protein 1B; KDM5B; Kiaa4034; lysine (K)-specific demethylase 5B; lysine demethylase 5B; lysine-specific demethylase 5B; mKIAA4034; PLU1; PLU-1; PPP1R98; protein phosphatase 1, regulatory subunit 98; PUT1; putative DNA/chromatin binding motif; putative DNA/chromatin binding motif 1; Rb-Bp2; RBBP2H1; RBBP2H1A; RBP2-H1; Retinoblastoma-binding protein 2 homolog 1; retinoblastoma-binding protein 2, homolog 1A; RGD1565602 | |
Mouse | |
Protein A | |
RUO | |
10765 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Your input is important to us. Please complete this form to provide feedback related to the content on this product.