Invitrogen™ KEAP1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA534454

Catalog No. PIPA534454

Description

A suggested positive control is human lung tissue lysate. PA5-34454 can be used with blocking peptide PEP-1496. The PA5-34454 immunogen is located within the last 50 amino acids of KEAP1. Predicted molecular ~ 70kD. In Western blot applications, this antibody has been observed to detect a band at: 65-70kD. Predicted species reactivity based on immunogen sequence: Pig: (100%).

This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.

Specifications

• Antigen: KEAP1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Keap1
• Gene Alias: cytosolic inhibitor of Nrf2; INrf2; Keap1; kelch like ECH associated protein 1; Kelch-like ECH-associated protein 1; kelch-like family member 19; kelch-like protein 19; Kiaa0132; KLHL19; mKIAA0132; NRF2 cytosolic inhibitor; ring canal protein
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 117519, 50868, 9817
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Immunohistochemistry (PFA fixed), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: P57790, Q14145, Q9Z2X8
• Gene Symbols: Keap1
• Immunogen: A peptide near the carboxy terminus of human KEAP1.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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