Invitrogen™ KEAP1 Recombinant Rabbit Monoclonal Antibody (PSH0-90)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA549609

Catalog No. FERMA549609

Description

Sequence Similarities: 98% Mouse/Rat. Tissue Specificity: Broadly expressed, with highest levels in skeletal muscle. Positive Control: HepG2 cell lysate, HeLa cell lysate, MCF7 cell lysate, A431 cell lysate, Jurkat cell lysate, HEK-293 cell lysate, Daudi cell lysate, A549 cell lysate, NIH/3T3 cell lysate, PC-12 cell lysate, mouse kidney tissue, rat kidney tissue, PC-12. Subcellular Location: Cytoplasm, Nucleus. Predicted band size: 70 kDa.

This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.

Specifications

• Antigen: KEAP1
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: P57790, Q14145, Q9Z2X8
• Gene Symbols: Keap1
• Immunogen: Recombinant protein within human keap1 aa 275-624/624.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Clone: PSH0-90
• Conjugate: Unconjugated
• Gene: Keap1
• Gene Alias: cytosolic inhibitor of Nrf2; INrf2; Keap1; kelch like ECH associated protein 1; Kelch-like ECH-associated protein 1; kelch-like family member 19; kelch-like protein 19; Kiaa0132; KLHL19; mKIAA0132; NRF2 cytosolic inhibitor; ring canal protein
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 117519, 50868, 9817
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid