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Invitrogen™ KHDRBS2 Polyclonal Antibody
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Catalog No. PIPA5112999
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100 μg
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Catalog No. Quantity
PIPA5112999 100 μg
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Catalog No. PIPA5112999 Supplier Invitrogen™ Supplier No. PA5112999
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Description

Rabbit Polyclonal Antibody

KHDRBS2 Polyclonal Antibody for ELISA, IHC (P), Western Blot

RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. Can regulate alternative splicing of NRXN1 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. Regulates cell-type specific alternative splicing of NRXN1 at AS4 and acts synergistically with SAM68 in exon skipping. In contrast acts antagonistically with SAM68 in NRXN3 exon skipping at AS4. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. May function as an adapter protein for Src kinases during mitosis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen KHDRBS2
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
Gene KHDRBS2
Gene Accession No. Q5VWX1, Q9WU01
Gene Alias 6330586C16Rik; hSLM-1; KH domain containing, RNA binding, signal transduction associated 2; KH domain-containing, RNA-binding, signal transduction-associated protein 2; KH RNA binding domain containing, signal transduction associated 2; Khdrbs2; mSLM-1; rSLM-1; Sam68-like mammalian protein 1; Slim1; SLM1; SLM-1
Gene Symbols KHDRBS2
Host Species Rabbit
Immunogen Recombinant Human KH domain-containing, RNA-binding, signal transduction-associated protein 2 protein (1-349AA).
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 170771, 202559
Target Species Human, Mouse
Content And Storage -20°C or -80°C if preferred
Product Type Antibody
Form Liquid
Isotype IgG
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