Invitrogen™ KHDRBS2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5112999

Catalog No. PIPA5112999

Description

KHDRBS2 Polyclonal Antibody for Western Blot, IHC (P), ELISA

RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. Can regulate alternative splicing of NRXN1 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. Regulates cell-type specific alternative splicing of NRXN1 at AS4 and acts synergistically with SAM68 in exon skipping. In contrast acts antagonistically with SAM68 in NRXN3 exon skipping at AS4. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. May function as an adapter protein for Src kinases during mitosis.

Specifications

• Antigen: KHDRBS2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KHDRBS2
• Gene Alias: 6330586C16Rik; hSLM-1; KH domain containing, RNA binding, signal transduction associated 2; KH domain-containing, RNA-binding, signal transduction-associated protein 2; KH RNA binding domain containing, signal transduction associated 2; Khdrbs2; mSLM-1; rSLM-1; Sam68-like mammalian protein 1; Slim1; SLM1; SLM-1
• Host Species: Rabbit
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 170771, 202559
• Content And Storage: -20°C or -80°C if preferred
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 3.5 mg/mL
• Formulation: PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
• Gene Accession No.: Q5VWX1, Q9WU01
• Gene Symbols: KHDRBS2
• Immunogen: Recombinant Human KH domain-containing, RNA-binding, signal transduction-associated protein 2 protein (1-349AA).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG