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Tocris Bioscience™ Ki 8751
Potent, selective VEGFR-2 inhibitor
Supplier: Tocris Bioscience™ 2542/50
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DescriptionKi 8751 is a potent, selective inhibitor of VEGFR-2 tyrosine kinase (IC50 = 0.9 nM). Displays some inhibitory activity towards c-Kit, PDGFRα and FGFR-2 (IC50 values range from 40 to 170 nM) but is highly selective over other receptor tyrosine kinases (IC50 > 10000 nM for FGFR-2, EGFR and HGFR). Inhibits VEGF-stimulated proliferation of human umbilical vein endothelial cells (HUVEC) and inhibits tumor growth in vivo; antiangiogenic.
|Soluble to 100mM in DMSO|
|Observed MW: 469.41|
Safety and Handling
Recommended Storage : Store at 4°C
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