Tocris Bioscience Ki 8751
Potent, selective VEGFR-2 inhibitor
Manufacturer: Tocris Bioscience 2542/50
DescriptionPotent, selective inhibitor of VEGFR-2 tyrosine kinase (IC 50 = 0.9 nM). Displays some inhibitory activity towards c-Kit, PDGFRα and FGFR-2 (IC 50 values range from 40 to 170 nM) but is highly selective over other receptor tyrosine kinases (IC 50 > 10000 nM for FGFR-2, EGFR and HGFR). Inhibits VEGF-stimulated proliferation of human umbilical vein endothelial cells (HUVEC) and inhibits tumor growth in vivo; antiangiogenic.
|Observed MW: 469.41|
|Soluble to 100mM in DMSO|
Safety and Handling
Recommended Storage : Store at +4°C
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