Ki67 Mouse anti-Human, Clone: OTI15A4, lyophilized, TrueMAB
Mouse Monoclonal Antibody
Manufacturer: OriGene CF802429
Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCOKi-67 is a nuclear protein that is expressed during various stages in the cell cycle, particularly during late G1, S, G2, and M phases. The protein has a forkhead associated domain (FHA) through which it associates with euchromatin at the perichromosomal layer, the centromeric heterochromatin, and the nucleolus. Ki-67 is shown to have a cell cycle dependent topographical distribution with perinucleolar expression at G1, expression in the nuclear matrix at G2, and expression on the chromosomes during M phase. Ki-67 is commonly used as a proliferation marker because it is not detected in G0 cells, but increases steadily from G1 through mitosis. Ki-67 antibodies are useful in establishing the cell growing fraction in neoplasms. In neoplastic tissues, the prognostic value is comparable to the tritiated thymidine-labelling index. The correlation between low Ki-67 index and histologically low-grade tumors is strong. Ki-67 is routinely used as a neuronal marker of cell cycling and proliferation.
|Human recombit protein fragment corresponding to amino acids 1160-1493 of human MKI67 produced in E.coli.|
|Immunohistochemistry (Paraffin), Western Blot|
|PBS with 8% trehalose and no preservative; pH 7.3|
|KIA, MIB-, MIB-1, PPP1R105|
|-20° C, Avoid Freeze/Thaw Cycles|
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