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Ki67 Rat anti-Human, Clone: OTI3B6, lyophilized, TrueMAB™

Rat Monoclonal Antibody
Supplier: OriGene CF801343

Description
Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO
Ki-67 is a nuclear protein that is expressed during various stages in the cell cycle, particularly during late G1, S, G2, and M phases. The protein has a forkhead associated domain (FHA) through which it associates with euchromatin at the perichromosomal layer, the centromeric heterochromatin, and the nucleolus. Ki-67 is shown to have a cell cycle dependent topographical distribution with perinucleolar expression at G1, expression in the nuclear matrix at G2, and expression on the chromosomes during M phase. Ki-67 is commonly used as a proliferation marker because it is not detected in G0 cells, but increases steadily from G1 through mitosis. Ki-67 antibodies are useful in establishing the cell growing fraction in neoplasms. In neoplastic tissues, the prognostic value is comparable to the tritiated thymidine-labelling index. The correlation between low Ki-67 index and histologically low-grade tumors is strong. Ki-67 is routinely used as a neuronal marker of cell cycling and proliferation.Specifications
Ki67 | |
Monoclonal | |
Unconjugated | |
MKI67 | |
KIA, MIB-, MIB-1, PPP1R105 | |
Rat | |
Affinity Chromatography | |
RUO | |
4288 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Lyophilized |
Immunohistochemistry (Paraffin) | |
OTI3B6 | |
PBS with 8% trehalose and no preservative; pH 7.3 | |
P46013 | |
MKI67 | |
Human recombit protein fragment corresponding to amino acids 1160-1493 of human MKI67 produced in E.coli. | |
100 μg | |
Primary | |
Human | |
Antibody | |
IgG1 |
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