KIAA1524 Monoclonal Antibody (OTI2A1), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA808460

Catalog No. 50-168-2152

Description

Inhibition of protein phosphatase 2A (PP2A) activity has been identified as a prerequisite for the transformation of human cells. The protein, designated Cancerous Inhibitor of PP2A (CIP2A), interacts directly with the oncogenic transcription factor c-Myc, inhibits PP2A activity toward c-Myc serine 62 (S62), and thereby prevents c-Myc proteolytic degradation. In addition to its function in c-Myc stabilization, CIP2A promotes anchorage-independent cell growth and in vivo tumor formation. The oncogenic activity of CIP2A is demonstrated by transformation of human cells by overexpression of CIP2A. Importantly, CIP2A is overexpressed in two common human maligcies, head and neck squamous cell carcinoma (HNSCC) and colon cancer.

Specifications

• Antigen: KIAA1524
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: CIP2A
• Gene Symbols: CIP2A
• Immunogen: Human recombit protein fragment corresponding to amino acids 635-905 of human KIAA1524 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b

• Applications: Western Blot
• Clone: OTI2A1
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Alias: KIAA1524, p90
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 57650
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid