KIAA1524 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA583469

Catalog No. PIPA583469

Description

Immunogen sequence: KMPWQSSNHS FPTSIKCLTP HLKDGVPGLN IEELIEKLQS GMVVKDQICD VRISDIMDVY EMKLSTLASK ESRLQDLLET KALALAQADR LIAQHRCQRT QAET

Inhibition of protein phosphatase 2A (PP2A) activity has been identified as a prerequisite for the transformation of human cells. The protein, designated Cancerous Inhibitor of PP2A (CIP2A), interacts directly with the oncogenic transcription factor c-Myc, inhibits PP2A activity toward c-Myc serine 62 (S62), and thereby prevents c-Myc proteolytic degradation. In addition to its function in c-Myc stabilization, CIP2A promotes anchorage-independent cell growth and in vivo tumor formation. The oncogenic activity of CIP2A is demonstrated by transformation of human cells by overexpression of CIP2A. Importantly, CIP2A is overexpressed in two common human malignancies, head and neck squamous cell carcinoma (HNSCC) and colon cancer.

Specifications

• Antigen: KIAA1524
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Cip2a
• Gene Alias: AA408511, AU018569, C330027C09Rik, Cancerous inhibitor of PP2A, cancerous inhibitor of protein phosphatase 2A, Cip2a, Kiaa1524, p90, p90 autoantigen, p90 autoantigen homolog, Protein CIP2A, RGD1310335, RIKEN cDNA C330027C09 gene, similar to RIKEN cDNA C330027C09
• Host Species: Rabbit
• Purification Method: Anitgen affinity chromatography, Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 57650
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry, Immunohistochemistry, Immunohistochemistry (Paraffin)
• Concentration: 0.4 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide, pH 7.2
• Gene Accession No.: Q8TCG1
• Gene Symbols: Cip2a
• Immunogen: Recombinant protein corresponding to Human KIAA1524
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG