KIAA1598 Polyclonal Antibody, Bethyl Laboratories

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-156-8291	Bethyl Laboratories, Inc A304648AT	20 μL

Description

The recommended shelf life for this product is 1 year from date of receipt.

SHTN1 is a protein coding gene involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or ′clutch engagement′ within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Plays also a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons.

Specifications

• Antigen: KIAA1598
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: TBS with 0.1% BSA and 0.09% sodium azide
• Gene Alias: shootin-1; shootin1
• Gene Symbols: SHTN1
• Isotype: IgG
• Purification Method: Antigen affinity chromatography
• Product Type: Antibody

• Applications: Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human
• Gene Accession No.: A0MZ66
• Gene ID (Entrez): 57698
• Immunogen: Between 575 and 625
• Primary or Secondary: Primary
• Content And Storage: 4° C
• Gene: SHTN1