KIAA1598 Rabbit anti-Human, Rat, Polyclonal, Proteintech

Catalog No.	Quantity
50-173-4328	150 μL

Catalog No. 50-173-4328 Supplier Proteintech Group Inc Supplier No. 243831AP150UL

Description

Rabbit Polyclonal Antibody

SHTN1 is a protein coding gene involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or ′clutch engagement′ within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Plays also a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons.

Specifications

• Antigen: KIAA1598
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 0.17 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene: SHTN1
• Gene Accession No.: A0MZ66, A0MZ67
• Gene Alias: KIAA1598, shootin 1
• Gene Symbols: SHTN1
• Host Species: Rabbit
• Immunogen: KIAA1598 Fusion Protein Ag18294
• Purification Method: Antigen Affinity Chromatography
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 292139, 57698
• Target Species: Human, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG