Invitrogen™ KIDINS220 Polyclonal Antibody

Catalog No.	Quantity
PA14229	100 μg

Catalog No. PA14229 Supplier Invitrogen™ Supplier No. PA14229

Description

Rabbit Polyclonal Antibody

PA1-4229 detects the Kidins220 protein in human samples. PA1-4229 has been successfully used in Western blot procedures. The PA1-4229 immunogen is a synthetic peptide corresponding to residues A(1747) S S E S T G F G E E R E S I L(1762) of the human 220 kDa Kidins220 protein.

This gene encodes a transmembrane protein that is preferentially expressed in the nervous system where it controls neuronal cell survival, differentiation into exons and dendrites, and synaptic plasticity. The encoded protein interacts with membrane receptors, cytosolic signaling components, and cytoskeletal proteins, serving as a scaffold that mediates crosstalk between the neurotrophin pathway and several other intracellular signaling pathways. Aberrant expression of this gene is associated with the onset of various neuropsychiatric disorders and neurodegenerative diseases, including Alzheimer's disease. Naturally occurring mutations in this gene are associated with a syndrome characterized by spastic paraplegia, intellectual disability, nystagmus and obesity. Alternative splicing results in multiple transcript variants.

Specifications

• Antigen: KIDINS220
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.02% sodium azide
• Gene: Kidins220
• Gene Accession No.: Q9ULH0
• Gene Alias: 3110039L19Rik; AI194387; AI316525; ankyrin repeat-rich membrane spanning; ankyrin repeat-rich membrane spanning protein; ankyrin repeat-rich membrane-spanning protein; ARMS; C330002I19Rik; KIAA1250; KIDINS220; kinase D-interacting substance 220; kinase D-interacting substance of 220 kDa; kinase D-interacting substrate 220; kinase D-interacting substrate 220kDa; kinase D-interacting substrate of 220 kDa; kinase D-interacting substrate, 220kDa; MGC163482; mKIAA1250; truncated KIDINS220
• Gene Symbols: Kidins220
• Host Species: Rabbit
• Immunogen: Synthetic peptide corresponding to residues A(1747) S S E S T G F G E E R E S I L(1762) of human Kidins220.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 57498
• Target Species: Human
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG