Invitrogen™ KIDINS220 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5116475

Catalog No. PIPA5116475

Description

Positive controls: SH-SY5Y cell lysates, N2A, PC-12, human pancreas tissue, human breast cancer tissue, mouse brain tissue, SH-SY5Y.

This gene encodes a transmembrane protein that is preferentially expressed in the nervous system where it controls neuronal cell survival, differentiation into exons and dendrites, and synaptic plasticity. The encoded protein interacts with membrane receptors, cytosolic signaling components, and cytoskeletal proteins, serving as a scaffold that mediates crosstalk between the neurotrophin pathway and several other intracellular signaling pathways. Aberrant expression of this gene is associated with the onset of various neuropsychiatric disorders and neurodegenerative diseases, including Alzheimer's disease. Naturally occurring mutations in this gene are associated with a syndrome characterized by spastic paraplegia, intellectual disability, nystagmus and obesity. Alternative splicing results in multiple transcript variants.

Specifications

• Antigen: KIDINS220
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Kidins220
• Gene Alias: 3110039L19Rik; AI194387; AI316525; ankyrin repeat-rich membrane spanning; ankyrin repeat-rich membrane spanning protein; ankyrin repeat-rich membrane-spanning protein; ARMS; C330002I19Rik; KIAA1250; KIDINS220; kinase D-interacting substance 220; kinase D-interacting substance of 220 kDa; kinase D-interacting substrate 220; kinase D-interacting substrate 220kDa; kinase D-interacting substrate of 220 kDa; kinase D-interacting substrate, 220kDa; MGC163482; mKIAA1250; truncated KIDINS220
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 116478, 57498, 77480
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: Q9EQG6, Q9ULH0
• Gene Symbols: Kidins220
• Immunogen: Synthetic peptide within Human Kidins220 aa 1,325-1,374.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov