Invitrogen™ KIF24 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA525624

Catalog No. PIPA525624

Description

KIF24 Polyclonal Antibody for Western Blot, IHC (P), Flow

Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation. Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle. Plays an important role in recruiting MPHOSPH9, a negative regulator of cilia formation to the distal end of mother centriole.

Specifications

• Antigen: KIF24
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KIF24
• Gene Alias: 4933425J19Rik; 9430029L23Rik; bA571F15.4; C9orf48; KIF24; kinesin family member 24; kinesin-like protein KIF24
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography, Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 109242, 347240
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene Accession No.: Q5T7B8, Q6NWW5
• Gene Symbols: KIF24
• Immunogen: KLH conjugated synthetic peptide between 356-384 amino acids from the N-terminal region of human KIF24.
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG