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Invitrogen™ KIF2A Polyclonal Antibody
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Catalog No. PIPA5110684
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100 μL
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PIPA5110684 100 μL
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Catalog No. PIPA5110684 Supplier Invitrogen™ Supplier No. PA5110684
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: DNESVTVEWI ENGDTKGKEI DLESIFSLNP DLVPDEEIEP SPETPPPPAS SAKVNKIVKN RRTVASIKND PPSRDNRVVG SARARPSQFP EQSSSAQQNG SVSDISPVQA Highest antigen sequence indentity to the following orthologs: Rat - 94%, Mouse - 92%.

KIF2A, a gene encoding the kinesin family member 2A protein, plays a pivotal role in neuronal development and function. This gene is part of the kinesin-13 subfamily, characterized by its unique ability to depolymerize microtubules, which are essential components of the cytoskeleton responsible for maintaining cell shape, enabling motility, and facilitating intracellular transport. KIF2A is particularly significant in neural settings, where it regulates microtubule dynamics crucial for neuronal migration and dendritic development. Dysfunctional KIF2A, due to mutations, has been linked to early-onset neurodegenerative diseases such as progressive microcephaly and mental disabilities due to impaired microtubule regulation, reflecting its foundational role in correct brain development and architecture. Additionally, KIF2A is involved in spindle assembly and chromosome segregation during cell division, further cementing its importance in both neurodevelopment and general cellular functions.
TRUSTED_SUSTAINABILITY

Specifications

Antigen KIF2A
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Kif2a
Gene Accession No. O00139, Q9WV63
Gene Alias C530030B14Rik; CDCBM3; HK2; hypothetical protein; KIF2; kif2a; kif2-a; kif2a {ECO:0000250; kif2a.L; kinesin family member 2A; kinesin heavy chain family, member 2; kinesin heavy chain member 2; kinesin heavy chain member 2A; kinesin heavy chain member 2A L homeolog; Kinesin, heavy chain, 2; kinesin-2; Kinesin-like protein KIF2A; kinesin-related protein XKIF2; Kns2; M-kinesin; RCJMB04_9a7; UniProtKB:O00139}; Unknown (protein for MGC:133806); XELAEV_18008243mg
Gene Symbols Kif2a
Host Species Rabbit
Immunogen Recombinant Protein corresonding to Human KIF2A. Recombinant protein control fragment (Product #RP-102374).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3796, 84391
Target Species Human, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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