Invitrogen™ KIF2A Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5110684

Catalog No. PIPA5110684

Description

Immunogen sequence: DNESVTVEWI ENGDTKGKEI DLESIFSLNP DLVPDEEIEP SPETPPPPAS SAKVNKIVKN RRTVASIKND PPSRDNRVVG SARARPSQFP EQSSSAQQNG SVSDISPVQA.

KIF2A, a gene encoding the kinesin family member 2A protein, plays a pivotal role in neuronal development and function. This gene is part of the kinesin-13 subfamily, characterized by its unique ability to depolymerize microtubules, which are essential components of the cytoskeleton responsible for maintaining cell shape, enabling motility, and facilitating intracellular transport. KIF2A is particularly significant in neural settings, where it regulates microtubule dynamics crucial for neuronal migration and dendritic development. Dysfunctional KIF2A, due to mutations, has been linked to early-onset neurodegenerative diseases such as progressive microcephaly and mental disabilities due to impaired microtubule regulation, reflecting its foundational role in correct brain development and architecture. Additionally, KIF2A is involved in spindle assembly and chromosome segregation during cell division, further cementing its importance in both neurodevelopment and general cellular functions.

Specifications

• Antigen: KIF2A
• Classification: Polyclonal
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O00139, Q9WV63
• Gene Symbols: Kif2a
• Immunogen: Recombinant Protein corresonding to Human KIF2A. Recombinant protein control fragment (Product #RP-102374).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Conjugate: Unconjugated
• Gene: Kif2a
• Gene Alias: C530030B14Rik; CDCBM3; HK2; hypothetical protein; KIF2; kif2a; kif2-a; kif2a {ECO:0000250; kif2a.L; kinesin family member 2A; kinesin heavy chain family, member 2; kinesin heavy chain member 2; kinesin heavy chain member 2A; kinesin heavy chain member 2A L homeolog; Kinesin, heavy chain, 2; kinesin-2; Kinesin-like protein KIF2A; kinesin-related protein XKIF2; Kns2; M-kinesin; RCJMB04_9a7; UniProtKB:O00139}; Unknown (protein for MGC:133806); XELAEV_18008243mg
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3796, 84391
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid